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Classified as a selective Nicotinamide N-methyltransferase (NNMT) small-molecule inhibitor, this quaternary ammonium compound achieves around 38.4% oral bioavailability in rodent trials, an acceptable absorption rate for positively charged quinolinium derivatives that typically face poor intestinal permeability

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In rare cases, side effects may include allergic reactions, swelling, chest tightness, or difficulty breathing

Nrf2 activity is reduced in the skeletal muscles of sedentary elderly people [61]

Holbert CE, Foley JR, Murray Stewart T, et al

doi: 10.1007/s00109-019-01863-0 156