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It has been reported that increased levels of hydrogen peroxide are responsible for damage to -cells as a consequence of altered signaling pathways regulating insulin production (Jrns et al

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Upon activation by conditions inducing ER stress, CHAC1 expression is upregulated primarily through the PERK-eIF2-ATF3/4 signaling pathway, independent of other UPR branches like IRE1-XBP1

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