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This metabolic alteration, in turn, impedes the normal differentiation of MDSCs and fosters their accumulation within the tumor microenvironment (113)

(PubMed) Trupp RJ, Abraham WT

The intrarenal IS levels in rats with chronic renal failure were increased six-fold, and mice induced by IS for 8 weeks exhibited glomerular and vascular injury with increased CYP1A1 expression

10.1111/exd.15008 [DOI] [PubMed] [Google Scholar] Nasir Shah S., Khan I., Tul M

Further, 9-me-BC appears to decrease toxic inflammation in the brain by decreasing inflammatory cytokines which are known to disrupt cognitive function through microglial accumulation