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Notably, glutamate plays a key role in the proliferating cells, not only by contributing to amino acid biosynthesis, but also acts as a nitrogen donor for purine and pyrimidine nucleotides biosynthesis (58)

This in turn activates macrophage release of reactive oxygen species (ROS), leading to oxidative stress via the respiratory burst

The injured tendon is painful because, in its weakened state, it cant cope with the loads that it used to be able to cope with when you straighten your arm

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N Engl J Med 2007