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4.5 Mn transporters in neurons and glia Identifying transporters of Mn in neurons and glia is important, as these cells regulate brain Mn homeostasis and are primary targets of Mn neurotoxicity (Pajarillo et al., 2021)

Tyrosine kinase with Ig and EGF (epidermal growth factor) homology domain 2 (TIE-2), a receptor for the proangiogenic factor angiopoietin-2, is expressed on circulating m-MDSCs in melanoma patients, where TIE-2 + M-MDSCs overexpress immunosuppressive mediators and potently inhibit melanoma-specific T-cell responses (173)

Hearing Difficulties and Tinnitus in Construction, Agricultural, Music, and Finance Industries: Contributions of Demographic, Health, and Lifestyle Factors

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doi: 10.1038/s41598-018-30823-w 111

Additionally, IN delivery bypasses the gastrointestinal tract and hepatic first-pass metabolism, potentially leading to improved bioavailability of oral iron chelators like DFP (Pires et al., 2009