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The American Academy of Dermatology 2021 guidelines on isotretinoin monitoring state: "Clinicians should ask patients at every visit about over-the-counter supplements, vitamins, and herbal products, as these are frequently overlooked sources of hepatotoxic exposure" [12]

The application of artificial intelligence is summarized in Fig

PRP is short for Platelet Rich Plasma The clinician begins by drawing blood from the patient, which is run through a centrifuge (a machine that quickly rotates) to separate the plasma from the platelets

Gently swirl or roll the vial to dissolve the powder

The burden is highest during weeks 9-24 when both are escalating

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