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When injected into a muscle, the toxin finds the motor nerves, blocks exocytosis, and thus reduces the ability of the muscle to contract

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Bourne and Harris (2011) used LTP inducing protocols and EM three dimensional reconstructions of CA1 pyramidal neurons dendritic segments in acute hippocampal slices to show that plasticity inducing protocols produce a decrease in dendritic inhibitory PSD density that is counterbalanced by an extension of the individual PSD areas

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Elderly patients are more susceptible to dilutional hyponatremia induced by thiazide diuretics