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Depression can develop, and relationships can be ruined

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I ran a biochemical optimization program a while back, and one of the clients that I had in there, he tried methylene blue, and he only got up to a half a milligram or a milligram, and his mood was worse, his fatigue was worse, he had more anxiety, a bunch of problems that, you know, the dose was too low to say it was doing a pharmacological messing with his neurotransmitters