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Studies indicate thatlow levels may predispose peopleto depression

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We focused on the multilevel evaluation of the monotherapy and co-treatment effects on neurons in terms of cellular and molecular features in vitro, such as metabolic activity, level of reactive oxygen/nitrogen species, total antioxidant capacity, DNA damage, level of ATP, neurite outgrowth, cell cycle and proteins level involved in intracellular signaling pathways, with particular emphasis on autophagy correlated with p62 protein

Specifically, decreased expression of several K + channels, including the K 2P channels TREK1 and TRAAK, were found after oxaliplatin and paclitaxel treatment in rodent dorsal root ganglion neurons (Descoeur et al., 2014)