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We selected the G12D and G12V mutations because of their high frequency across all KRAS-driven cancers (including colorectal cancer) (Figure S1A), G12C for its high prevalence only in lung adenocarcinoma, and G12A because it is infrequently observed in colorectal adenocarcinoma yet biochemically indistinguishable from G12V 7

Basu S, Giri RK, Benazir I, Kumar S, Rajwanshi R, Dwivedi SK, et al

c-Myc can directly bind to the promoter regions of PHGDH and PSAT1 and promote their transcription, a mechanism that has been validated in breast cancer and glioblastoma (64, 98, 99)

Int J Pharm 420:122132 Van de Ven H, Vermeersch M, Vandenbroucke RE, Matheeussen A, Apers S, Weyenberg W, De Smedt SC, Cos P, Maes L, Ludwig A (2012) Intracellular drug delivery in Leishmania-infected macrophages: Evaluation of saponin-loaded PLGA nanoparticles

Type 3 innate lymphoid cells as an indicator of renal dysfunction and serum uric acid in hyperuricemia

Taken together, preclinical works have supported the role of imbalances in the accumbal glutamatergic system as a driver of addictive behaviors in rodents