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This stabilization activates the HIF1/VEGF/STAT3 signaling axis, contributing to redox homeostasis and enhancing tumor cell adaptation to hypoxic stress [140] (Fig

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In IDH-mutant gliomas, studies have observed an increase in mtDNA copy number, whereas no significant changes were found in recurrent cancers [197]

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These observations suggest that GPX4 expression and ferrous iron levels are upregulated in anti-colorectal cancer drug-tolerant cells and could hence be therapeutic targets for the selective eradication of persister cells