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Although some irAEs are more common with CTLA-4 inhibitors than with PD-1 or PD-L1 inhibitors, pneumonitis is more common in patients treated with PD-1 inhibitors, such as nivolumab or pembrolizumab, though the mechanism for this difference is unclear

doi: 10.1016/j.nut.2012.11.012 145 MahanDCClineTRRichertB

A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response

Novakova et al

However, in evolutionary context it makes sense, as Met-derived GSLs are a later invention in plant evolution (both in comparison to other types of GSL and other types of secondary metabolites), and during evolution plants made use of already existing transporters from primary metabolism

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