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Melatonin use is safe and did not show any teratogenic effects in both human and animal (9-10) as well as no toxicity (11) even at very high dose (5-20mg/day)

Also, effectively works on pimples and wrinkles

Long-term studies: Long-term follow-up studies are essential to evaluate the sustained impact of ESCM use on human health and to identify any potential long-term side effects or toxicity

This is the same mechanism targeted by topical brightening agents, delivered systemically instead, and the effect is best understood as a gradual, cumulative brightening support across a series rather than an overnight change