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Three trials of cognitive-behavioral therapy and two trials of mindfulness-based therapy demonstrated their superiority over wait-list control status

* Plasma samples were collected for all 53 participants, whereas urine samples were collected for 51 of the 53 participants (subjects 19 and 21, both females, did not provide urine samples)

40(12): 130510 Rebouche CJ, Engel AG

doi: 10.3389/fnins.2025.1602149 Received 28 March 2025 Accepted 21 May 2025 Published 04 June 2025 Volume 19 - 2025 Edited by Xiao-Yuan Mao, Central South University, China Reviewed by Cai Qi, Yale University, United States Fiorella Colasuonno, University of Rome Tor Vergata, Italy Updates Copyright 2025 Valenzuela-Ahumada, Mercado-Gmez, Viveros-Contreras, Guevara-Guzmn and Camacho-Morales

3.1 Cellular consequences of macrophage lipotoxicity Excessive intracellular accumulation of FFAs, termed lipotoxicity, can promote pro-inflammatory responses, disrupt cellular homeostasis, induce organelle dysfunction, and ultimately induce cell death in macrophages (69, 70, 80)