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Given the existence of the specific OCTN1 transporter and the selective accumulation in neural and metabolically active tissues, this raises the question of whether the Western decline in mushroom consumption compared to traditional cultures in Asia, where mushrooms have been a staple food for thousands of years may contribute to a chronic undersupply that could correlate with the rise of neurodegenerative disease

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GPX4, glutathione peroxidase 4

Through experiments in a PCOS mouse model and a KGN GC model, PLB significantly improved ovarian function, regulated hormone levels, enhanced antioxidant capacity, and promoted cell survival by inhibiting the ferroptosis pathway

It binds to HGF with high affinity (Kd = 65 pM) and markedly augments the capacity of HGF to activate c-Met phosphorylation, even at subthreshold concentrations of the growth factor

The significance of selenoproteins for human health revealed by inborn errors of metabolism