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doi: 10.1016/j.tem.2017.02.004

Six Phase I/II clinical trials enrolling approximately 900 participants confirmed an excellent safety profile with no serious adverse events attributed to the compound

It was identified through a medicinal chemistry programme at the University of Texas Health Science Center as the lead NNMT inhibitor candidate among a series of 1-methylquinolinium analogues bearing primary amine substitutions, selected for its combination of high passive membrane permeability (confirmed in PAMPA assays), high active transport membrane permeability (confirmed in bidirectional Caco-2 cell assays), potent NNMT inhibitory activity, and high selectivity including confirmed absence of inhibitory effects on related SAM-dependent methyltransferases or enzymes in the NAD+ salvage pathway

Proper storage and handling procedures are important for maintaining product purity, consistency, and reliability throughout laboratory applications

At Licensed Peptides, we integrate quality assurance into every stage of manufacturing and testing

Because AOD 9604 does not bind the growth hormone receptor, it does not trigger the IGF-1 cascade