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doi: 10.1016/j.jenvrad.2016.09.019

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Binding of cGAMP induces a conformational change that facilitates oligomerization of STING dimers and STING activation (138140)

In order to gain insight into a potential role of GR in the cellular radiation response we treated the cancer cells with the documented GR inhibitor 2-acetylamino-3-[4-(2-acetylamino-2- carboxyethylsulfanylthio-carbonylamino)-phenylthiocarbamoylsulfanyl]propionic acid (AAPA) ( Figure 5A )