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Retrieved February 4, 2020

Although it is mostly converted to nontoxic metabolites by sulfation and glucuronidation, a small amount of the drug is metabolized by cytochrome P450 enzymes (including subtype 2E1) into the toxic metabolite N-acetyl-p-benzoquinone imine (NAPQI)

Hydrogels and Implantable Systems Unlike drop-based nanoparticles, hydrogels and implants provide a depot effect for sustained release, reducing the burden of patient compliance

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