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These include using biodegradable backbones or enzymatically cleavable linkers, surface neutralization (for example hydroxylation, carboxylation or PEGylation) to reduce cationic surface reactivity, minimizing generation/size for dendrimers while preserving targeting, and requiring chronic-dosing safety packages that measure persistent microglial activation and behavioral outcomes before first-in-human trials

[29] The thiol group also has a high affinity for heavy metals, so that proteins containing cysteine, such as metallothionein, will bind metals such as mercury, lead, and cadmium tightly

2B), probably due to a slight increase in the GAPDH protein level (Fig

When respiratory inflammation occurs, these mucins form thick, viscous plugs that are incredibly difficult to clear, leading to chronic congestion and shortness of breath

Metabolite treatment increased the endogenous levels of individual treated metabolites in each treatment group compared to the control group (Supplementary Fig

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