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JMIR Formative Research , 6(5), e35706

Highly lipophilic compounds tend to accumulate in peripheral tissues, potentially causing systemic toxicity, while polar molecules often fail to effectively reach central targets (169)

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Future research must concentrate on targeted delivery, combination medicines, and biomarker discovery to tackle the problems and future trajectories of antioxidants in cancer therapy

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Instead, plans will use WAC as the base for gross drug cost calculations, and manufacturers will pay rebates through a new PDE field called Facilitated DIR (FAD)