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2025;6:1002337 DOI: Received: July 01, 2025 Accepted: September 08, 2025 Published: September 23, 2025 Academic Editor: Luca Falzone, University of Catania, Italy The article belongs to the special issue Predictive and Prognostic Biomarkers in Cancer: Towards the Precision Medicine Era Microsatellite-stable metastatic colorectal cancer (MSS mCRC) is currently treated with chemotherapy and targeted agents based on RAS and BRAF mutational status