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This was enabled by a dual fluorescence ENL stability reporter (ENL-TagBFP-P2A-mCherry) expressed in KBM7 cells harboring a doxycycline-inducible Cas9 expression cassette (Extended Data Fig

Therefore, future research should explore the interplay among various PCD pathways, identify key molecular nodes, and leverage multi-omics technologies to construct a comprehensive PCD regulatory network associated with DOR