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Youre essentially on your own

Short-term dose response studies clearly demonstrate that older patients require a lower GH dose to maintain a given serum IGF-I level (35,36), and it has been observed that serum IGF-I increases in individual patients on long-term therapy if the GH dosage remains constant

Experimental investigations involving Epithalon have primarily focused on its molecular signaling properties, gene expression modulation, and chromosomal endpoint behavior under laboratory conditions

What about the frequency

Its designers proposed that it acts as a positive modulator of the HGF/c-Met system, a genuine neurotrophic axis with documented roles in neurite outgrowth and synaptic plasticity [5]

They sit near the top of the evidence hierarchy, just below meta-analyses (which combine multiple RCTs)