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Feldman H, Blackmon S, Lawton JS, Antonoff MB

Many biochemical and molecular strategies, such as upregulated antioxidant genes and proteins and upregulation of antioxidant transcribing systems such as NRF2-Keap1 system, are adapted by fish to challenge the environmental stressors

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In ALS models, SOD1 mutations do not markedly alter astrocytic baseline states but lower the threshold for reactivity, which sensitizes astrocytes to oxidative, glutamatergic and inflammatory stress and drives exaggerated reactive responses to otherwise moderate insults 80

It forms the building block of the skin and is responsible for its natural elasticity