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Personalized medicine is essential for managing chronic infections, where factors such as multidrug-resistant pathogens, biofilms, and diverse immune responses complicate treatment [230]

The FDA label (NDA 021446) lists the following key pharmacokinetic parameters: oral bioavailability greater than 90%, linear pharmacokinetics up to 600 mg/day, renal elimination as unchanged drug (greater than 98%), and no meaningful hepatic CYP metabolism [4]

Leukemia 30:399408 de Weers M, Tai YT, van der Veer MS, Bakker JM, Vink T, Jacobs DC et al (2011) Daratumumab, a novel therapeutic human CD38 monoclonal antibody, induces killing of multiple myeloma and other hematological tumors

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Vitamin B17 was administered intraperitoneally at different doses (5 mg/kg, 10 mg/kg and 20 mg/kg) 24 h post-reperfusion for a duration of 3 consecutive days