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NAC is generally safe and well-tolerated, making it a reasonable option for individuals with oxidative stress or glutathione deficiencies

XS and NH revised the manuscript

However, we do not fully understand why these aging hallmarks occur in the first place, and therefore there have been no proven solutions via human randomized clinical trials to improve or correct aging hallmarks in aging humans. The aging hallmarks that improved are mitochondrial dysfunction, altered intercellular communication, nutrient sensing, loss of proteostasis, genomic instability, cellular senescence and stem cell fatigue

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