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10.3748/wjg.14.2639 44 HanY.LiuD.ChengY.JiQ.LiuM.ZhangB.et al (2023)

Genetics and epigenetics of Alzheimers disease: understanding pathogenesis and exploring therapeutic potential

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Under normal physiological conditions, reduced GSH is present in concentrations 10 to 100 times greater than oxidized GSH (GSSG), making the GSH/GSSG ratio a common measure of cellular oxidative stress ( The function of GPX4 is precisely regulated by nuclear factor E2-related factor 2 (NRF2), a key transcription factor that activates the expression of various antioxidant genes, including those encoding GSH synthetase and superoxide dismutase (SOD), facilitating the clearance of excess ROS (Xie et al., 2016

L-DOS47 elevates pancreatic cancer tumor pH and enhances response to immunotherapy

Greb A, Bitsch R