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Leigh syndrome with spinal cord involvement due to a hemizygous NDUFA1 mutation

These features explain why absorption-side variants such as those in CUBN tend to manifest slowly and why bypassing absorption entirely (through injection) is the classic remedy when the ileal machinery is genetically compromised

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The disruption of these precisely regulated networks is now acknowledged as a causative element in both male and female infertility, leading to vigorous attempts to develop medications that either block pathogenic ncRNAs or restore protective ones

Intriguingly, another interesting research lead to the discovery of a differential role for IRSs in apoptosis, suggesting an antiapoptotic effect for IRS-2 [122] which is consistent with known differential roles of IGF-1 and insulin

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