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The average survival time ranges from 2 to 5 years post-diagnosis, and respiratory failure is the primary cause of mortality

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In KRAS-mutant cancer cells with or without LKB1 loss, increased expression of SSP genes and high serine synthesis allow the cells to tolerate serine starvation for survival (Kottakis et al., 2016

BefA increased -cell mass during development and in adult animals, improving glycemic control in diabetic mice, thus pointing to the possibility of direct modulation of -cell plasticity by the microbiota (Hill et al., 2022)

These findings suggest that iron overload promotes iron transport and disrupts the antioxidant system [42, 43]