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Reversing this stress, the body generates more of it in response as a protection strategy

[Paeoniaceae, Paeonia lactiflora root] as its primary metabolite, exerts antidepressant effects through multiple targets and pathways

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This is particularly interesting because it demonstrates FOXO4-DRI's senolytic activity extends to endocrine tissues and can restore hormonal function, not just structural tissue integrity

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Nrf2 inhibition dampens the antioxidant response and sensitises cells to cisplatin Nrf2 is a master regulator of the antioxidant system