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BSO treatment was not included, because this already induced a significant oxidative stress response (data no shown)

In addition, those bound platelets presented upregulated expression of p-selectin and -thromboglobulin, indicating that these platelets have been activated and this platelet-activated response could directly happen on the transplanted islets

Oxidatively modified phosphatidylserines on the surface of apoptotic cells are essential phagocytic eat-me signals: cleavage and inhibition of phagocytosis by Lp-PLA2

While the filtered GSH is degraded stepwise by the action of the brush-border enzymes -glutamyltransferase and cysteinylglycine dipeptidase, the remainder of the GSH appears to be transported via an unrelated, Na+-dependent system present in basal-lateral membranes