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Such bidirectional control becomes particularly relevant in chronic pain, where thalamic plasticity alters connectivity, excitability, and rhythmicity, leading to thalamocortical dysrhythmia that amplifies nociceptive salience and sustains persistent pain (81, 82)

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Urinary levels of 2-OPP showed a significant positive correlation with -AASA, and the highest levels of 2-OPP in the CSF were observed in patients treated with vitamin B6