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Introduction Myelodysplastic syndromes (MDS), also known as myelodysplastic neoplasms per the WHO 2022 classification, 1 are clonal hematopoietic stem cell disorders characterized by ineffective blood cell production, dysplasia of blood and bone marrow cells and an increased risk of progressing to acute myeloid leukemia (AML)

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at the same 1 ng/ml) displayed lower activation activity than the maximum level of the LASSS-treated HGF, aligning with the established HGF-dose-dependent manner of satellite cell activation with maximum at 2.510 ng/ml on the same in vitro assay platform (see Figure inset, reproduced from Tatsumi et al

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