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If the proposed mechanism (gradual synaptic plasticity effects) is right, daily dosing might be needed for sustained effect

A: Injections deliver B12 directly into the muscle for maximum absorption, bypassing the digestive system where much of the vitamin may be lost

Amsterdam: Elsevier Inc

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Gastrointestinal side effects are the most commonly reported adverse events associated with retatrutide in clinical trials, consistent with the broader class of incretin-based therapies