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Unlike full-length growth hormone, AOD-9604 does not upregulate IGF-1, does not induce insulin resistance in reported toxicology models, and does not measurably affect linear growth in adult animal models

Adding too much water dilutes the solution, potentially requiring larger injection volumes that increase discomfort

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Older people usually produce less stomach acid and therefore less intrinsic factor, increasing their risk for deficiency

24 25 Some patients may experience recurrence or worsening of symptoms when the interval between injections is extended or extended too quickly, and report that continuation of frequent intramuscular hydroxocobalamin injections, varying between twice weekly and once every three to four weeks, 65 is needed to remain asymptomatic

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