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Front Endocrinol 13:920340 Lee HY, Ithnin A, Azma RZ, Othman A, Salvador A, Cheah FC (2022) Glucose-6-phosphate dehydrogenase deficiency and neonatal hyperbilirubinemia: insights on pathophysiology, diagnosis, and gene variants in disease heterogeneity

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[2] Une particularit notable : une grande partie de la NAC absorbe est transforme ds son passage par le foie

When detoxification capacity is overwhelmed: Oxidative stress rises Mitochondrial efficiency declines Cellular recovery slows Pain sensitivity increases This creates a compounding effect: impaired detoxification further strains nutrient reserves, and diminished nutrient reserves reduce detox efficiency