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Orthopedics 37: e678-e684

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Following sciatic nerve injury, localized mechanical stress and ischaemia-reperfusion rapidly trigger a sterile inflammatory response centred on macrophages and neutrophils 5

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Chronic coughing, heavy lifting, obesity, pregnancy, and chronic constipation all increase abdominal pressure, which can worsen existing hernias or create new ones

Notably, a significant decrease in the expression of gnd , which is pivotal for NADPH production and thus essential for maintaining cellular redox homeostasis and GSH levels, was observed in the GR mutant compared to the WT strain (Figure 4A), suggesting that GR knockout leads to important alterations in metabolic processes, particularly carboxyltransferase activity and carbohydrate metabolism, consistent with our earlier observations