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It is reported that the K48-linked polyubiquitin chain is recognized by the proteasome, leading to the degradation of the substrate protein 6,9

IACS-010759, a potent small-molecule inhibitor of mitochondrial complex I, has demonstrated significant antitumor activity in high OXPHOS cancer models, including acute myeloid leukemia (AML) and glioblastoma [521]

The balance between these two effects determines the steady state concentration of GSH

Main text By-products of O 2 metabolism, detoxification mechanisms and the role of oxidative stress Mitochondrial oxidative phosphorylation is the final stage of cellular respiration, following glycolysis, pyruvate oxidation and the citric acid cycle

Astrocyte Calcium Signaling: from observations to functions and the challenges therein

Finally, the fourth mechanism entails target modification, which can occur through mutations, enzymatic alterations, and replacement 19,64,65