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When activated, mast cells release a complex array of mediators: histamine, tryptase, leukotrienes, prostaglandins, and a range of cytokines

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These include many of the most widely used clinical peptides, the same molecules currently supplied to medical clinics by research-grade laboratories

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5 had undergone LT and 12 were or had been in evaluation for LT

The subcellular localization of differentially expressed proteins further confirmed this