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Additionally, four arginine residues (Arg198, Arg132, Arg273, Arg278) form a positively charged region covering the active-site cavity, which might be used to manipulate the negatively charged substrates [177]

Gas chromatographymass spectrometry (GC-MS): A comprehensive review of synergistic combinations and their applications in the past two decades

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(PubMed) Carr AC, Maggini S

This is the result of a continuous adaptation of the gonococcus to its diverse ecological niche, an adaptation influenced by the use/misuse of antibiotics in more recent times, and which has mainly involved: i