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Figure 3 3.1 TLR-nuclear factor kappa B signaling pathway As one of the earliest identified PRR families, TLRs comprise 10 members in humans (TLR1-10) and 12 in mice (TLR1-9, 11-13) ( Simultaneously, the IRAK-TRAF6 complex activates mitogen-activated protein kinase kinase (MKK) cascades, thus leading to activation of activator protein 1 (AP-1), which is another critical transcription factor in inflammation ( Figure 4 )

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Furthermore, adding back haemin to the HD medium restored the reduced expression levels of SDHB and Rieske, as well as mitochondrial respiration, whereas adding back the iron derivative FAC did not, suggesting a haem-specific function for mitochondria (Fig

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CK2, a constitutive Ser/threonine (Thr) kinase, is a suppressor of FUNDC1 that promotes its phosphorylation at Ser13, thus effectively preventing its association with LC3 and inhibiting mitophagy (92)