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Exposure to allergens, pollutants, respiratory infections, and stress can trigger immune responses, leading to airway inflammation

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Cells generate localized ROS near the nuclear envelope (NOX isoforms), the outer mitochondrial membrane (MAO facing the cytosol) and cytosolic dehydrogenase complexes adjoining the nucleus (Kaludercic et al

However, when it was tested in humans, it worsened stroke outcome and was associated with ICH, cardiac arrest, and meningitis [113,129]