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Compounds outside that system may eventually be approved, but until they are, the evidence base is by definition incomplete

After a sterile package is opened, the edges are considered unsterile

These are more considerations of medications affecting vitamin status (rather than the vitamin affecting the medication), but they illustrate the clinical judgment required when co-administering this injection with certain treatments

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high uPAR expression reduces tamoxifen efficacy in patients [206] and confers resistance to tamoxifen in MCF-7 cells, and to doxorubicin and paclitaxel in MDA-MB-231 cells [207]