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A strand can be considered to have multiple fragments if it has a gap between two double-stranded regions or a single-stranded region of mismatched nucleotides

Biomarker Framework: Glutathione Status and GLP-1 Treatment Context Clinical assessment of glutathione relies on indirect biomarkers rather than direct measurement in most settings

J Neurosci 35:52845292

These cells are also specialized to recognize bacterial-derived molecules, known as prokaryotic-associated molecular patterns, with the help of the Toll-like receptors on the cell surface and the nucleotide-binding oligomerization domain-like receptors in the cytoplasm, which activate defense mechanisms by the secretion of anti-microbial peptides 2