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Treatment of acute sciatica with transforaminal epidural corticosteroids and local anesthetic: design of a randomized controlled trial

Ann Rheum Dis 79:685699

[224] demonstrated that oxidative stress triggers mtDNA leakage, which activates the cGASSTING pathway and induces the secretion of pro-inflammatory cytokines in human iPSC-derived neurons

In highly sensitive, cytokine-driven Th2 inflammation, leaving 25% residual p-STAT6 active is a recipe for a clinical efficacy ceiling

To address this need, chemists have developed multiple novel types of H 2 S donors over the past decade that can be activated in response to different triggers, such as hydrolysis, biological thiols, light, pH, and enzymes (Figure 1) ( 2 S in the presence of biological thiols (e.g., glutathione, GSH) and glucose ( 2 S via hydrolysis ( 2 S predominantly through exchange reactions with endogenous thiols (e.g., GSH) ( 2 S release occurs following nucleophilic addition by a thiol ( 2 S upon hydrolysis with controlled kinetics ( 2 S ( 2 S donors has become imperative to overcome current therapeutic limitations

PMCID: PMC4324542.