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The compound's development represents years of medicinal chemistry optimization, resulting in a 10-fold improvement in potency over parent compounds while maintaining excellent safety margins in preclinical studies

FEBS J (2018) 285(10):175166

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Semaglutide showed 15 to 17 percent of body weight over 68 weeks

Figure 5: Changes in tissue weight in lean mice and obese mice across the three different experimental treatment groups