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Abbreviations ATI/II: alveolar type I/II CAD: C-terminal transactivation domain CO: carbon monoxide EPO: erythropoietin GSSG: glutathione oxidized disulfide H 2 O 2 : hydrogen peroxide HBS: HIF-binding site HIF-: hypoxia-inducible factor-1 HIF-PH: HIF- prolyl-hydroxylase HRE: hypoxia responsive element IB: inhibitory B ICE: IL-1-converting enzyme IL: interleukin NAC: N -Acetyl-L-cysteine

SHVRI-SV-20230616-03, and SHVRI-20230602-01), and animal experiments were conducted following the Guidelines on the Humane Treatment of Laboratory Animals after approval