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Moreover, metabolites like itaconate degrade more rapidly in human CSF, with a half-life of 1.2 h compared to 4 h in mice [222]

In the STEP-4 clinical trials, participants who discontinued the medication began to regain weight within a few months

An increased level of vascular oxidative stress and expression of NADPH oxidase subunits (p47phox and p22phox), COX-1 and COX-2, endothelial NO synthase and Ang II type 1 receptors were observed in the Ang II group, whereas SKCa and connexin 37 were downregulated

These findings underscore the potential role of gut microbiota in the pathogenesis and progression of PCOS

Keene and Appelbaum 2019

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