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Avoid alkaline pH conditions and prolonged exposure to elevated temperatures that promote peptide degradation

Luminidependens (LD) is an Arabidopsis protein with prion behavior

Terzi et al., 2015)

In the process of physiological ageing, both systemic and tissue-specific systems show functional downfalls, which, when projected to the brain, translate into weakening defence and metabolic strain resulting from age-dependent declines of the cardio-vascular system and overall decreases in metabolism

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The tBid promotes the activation of mitochondrial outer membrane permeabilization (MOMP) effector proteins BAX and BAK, which further trigger the recruitment of other caspases to perform apoptosis [148]