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Many methodological validations were not included because of the limited space of the article

Because tumor growth also depends on new blood vessels, several reviews describe this as a theoretical concern that has not been resolved in humans (Sehgal et al., Pharmaceuticals, 2025)

Human trials have predominantly used topical or brief systemic dosing, and tolerability is overall reported to be good

Subcutaneous / intraperitoneal route Used for systemic studies

But promise without proof is hypothesis, not treatment

SUSTAIN 5: A 30-week, randomized, double-blind, placebo-controlled, parallel-group trial in 397 adult patients with type 2 diabetes evaluating the addition of Ozempic injection 0.5 mg and Ozempic injection 1 mg to basal insulin metformin